HOCl Performance Stabilized

What are the key clinical benefits of Performance Stabilized HOCl (hypochlorous acid)?

Hypochlorous acid (HOCl) is a compound that is produced naturally by Neutrophils in the immune system to eradicate microorganisms. HOCl immediately relieves itch and pain, kills bacteria and breaks down biofilm, does not sting or irritate skin and oxygenates the cells in the area treated assisting the body in its natural healing process. The Performance Stabilized HOCl has been formulated to deliver maximum benefits safely throughout the life of the product.

Cleanse

Relieve

Relieve

Restore

TRIPLE MODE OF ACTION

3X

Based on one of the body’s most important molecules, Hypochlorous acid (HOCl), our Performance Stabilized HOCl formulation has a Triple Mode of Action and profound impact on infection, inflammation, and scarring.

Anti-microbial

In-vitro and clinical studies of our Performance Stabilized Hypochlorous Acid breaks down the biofilm along with having impressive anti-pruritic, anti-microbial, anti-viral, and anti-inflammatory properties.

Anti-inflammatory

A powerful anti-inflammatory, our Performance Stabilized Hypochlorous Acid treats common conditions while reducing infections, itch, pain, scarring, and harmful inflammatory responses.

Regenerative

A gentle and safe solution that increases oxygen to the area in need and helps accelerate the body’s natural healing process.

In-vitro and clinical studies of Hypochlorous Acid (HOCl) show it to have impressive antipruretic, antimicrobial and anti-inflammatory properties. The exclusive Performance Stabilized HOCl formulation not only optimizes HOCl for superior efficacy and safety, it guarantees potency for the life of the product. With virtually no side effects or contraindications, you can utilize Performance Stabilized HOCl as often as needed to cleanse skin, relieve irritations and restore your well-being and peace of mind.

Cleanse

Safely eradicates biofilm and other irritants.

Potent Antimicrobial1

Time Kill Study: In Vitro in solution HOCl Eradication of Pathogens

Greater than 99% reduction in killing 23 different microorganisms

Breaks Down Bacterial Biofilm6

Biofilm formation is recognized as a serious problem in chronic wound infections. HOCl has antibiofilm activity and actively breaks down biofilm and kills microorganisms within the biofilm. Biofilm characteristics include:

  • Complex structure of microorganisms that generate a protective shell, allowing bacteria to collect and proliferate
  • Most microorganisms that form biofilms found growing in microbial infection
  • Adheres to chronic wounds, makes phagocytosis difficult, and increases resistance to antibiotics

Relieve

Reduce pain, itch and swelling fast.

Reduction in Pain and Itch

Study 1: Open-Label Study2

Open-label, single-arm study over 7 days

Results

HOCl rapidly reduces pruritus in mild-to-moderate atopic dermatitis (AD)

Study 2: Randomized, Blinded, Controlled Study3

  • 72-hour study
  • Treated group (n=19): HOCl BID
  • Untreated group (n=10): No treatment

Results

The mean pruritus VAS scores saw a greater improvement among the treated group than the untreated group between baseline and 72 hours post application

Anti-Inflammatory Activity4

HOCl for Inhibition of Mast Cell Degranulation

  • Prevents allergen and calcium-induced mast cell degranulation for up to 8 hours after a single exposure in vitro
  • Reduces wound inflammation that inhibits healing

  • Stabilizes the mast cell membrane to inhibit the cell machinery for granule secretion, while not altering the signal transduction pathways or calcium mobilization
  • Inhibits degranulation stimulated by antigen or calcium ionophore
Cleanse

*A23187 + PMA is a calcium ionophore; †b-hexosaminidase is a marker of IgE-antigen-induced mast cell degranulation.

Restore

Increasing oxygen to the area in need helps accelerate the body’s natural healing process.

Increases Oxygenation5

  • Provides higher levels of oxygen at a wound site after application
  • Elevated blood and oxygen flow increases wound-healing nutrients
  • HOCl is a known vasodilator
Wipe face

Assists Wound Healing6

Wound healing involves a complex sequence of events. Fibroblasts are the primary synthetic cells in the repair process of most structural proteins used during tissue reconstruction.

At lower concentrations of HOCl, the percentage of fibroblast migration exceeded that of the control at 24 hours.

Effect of HOCl on Skin Fibroblast Cell Migration in a Wound Healing Assay

References: 1. Data on File. IntradermPharmaceuticals. 2. Draelos Z, Cash K. Evaluation of a gel formulation of hypochlorous acid and sodium hypochlorite to reduce pruritus in mild to moderate atopic dermatitis. Poster presented at: The Winter Clinical Dermatology Conference. January 14-19, 2012; Maui, HI. 3. Berman B, Nestor M. Investigator blinded randomized study evaluation HOCl in the treatment of atopic dermatitis-associated pruritus. Poster presented at: The Fall Clinical Dermatology Conference. Oct 12-15, 2017; Las Vegas, NV. 4. Medina-Tamayo J, Sánchez-Miranda E, Ballez-Tapia H, et al. Super-oxidized solution inhibits IgE-antigen-induced degranulation and cytokine release in mast cells. Int Immunopharmacol. 2007; 7(8): 1013-2014. 5. Bongiovanni CM. Superoxidized water improves wound care outcomes in diabetic patients. Available at: http://www.microdacyn.pl/pdf/7ART-02-Bongiovanni-DMC-05-2006.pdf. Accessed September 9, 2017. 6. Sakayra S, gunay N, Karakulak M, et al. Hypochlorous acid: An ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. Wounds. 2014;26(12):342-350.